IGFBP-2 partly mediates the early metabolic improvements caused by bariatric surgery

IGFBP-2 partly mediates the early metabolic improvements caused by bariatric surgery

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Summary: Insulin-like growth factor-binding protein (IGFBP)-2 is a circulating biomarker of cardiometabolic health.Here, we report that circulating IGFBP-2 concentrations robustly increase after different bariatric procedures in humans, reaching higher levels after biliopancreatic diversion with duodenal switch (BPD-DS) than after Roux-en-Y gastric bypass click here (RYGB) and sleeve gastrectomy (SG).This increase is closely associated with insulin sensitization.In mice and rats, BPD-DS and RYGB operations also increase circulating IGFBP-2 levels, which are not affected by SG or caloric restriction.

In mice, Igfbp2 deficiency significantly impairs surgery-induced loss in adiposity and early improvement in insulin sensitivity but does not affect long-term enhancement in glucose homeostasis.This study demonstrates that the modulation of circulating IGFBP-2 may play a role in hiboost 4k smart link the early improvement of insulin sensitivity and loss of adiposity brought about by bariatric surgery.